Introduction and Workflow
- Epigenomics Sequencing is a comprehensive approach to analyze epigenetic modifications across genomes, providing enriched genomic view of cellular memory and gene regulation.
- The workflow includes isolating DNA, fragmenting it, capturing the regions of interest followed by sequencing to produce millions of short reads.
- In the bioinformatics analysis, these reads are aligned to a known reference genome to detect genomic alterations and epigenetic modifications.
- It is a powerful tool for diverse genomic studies, capable of sequencing humans, livestock, plants, bacteria, and disease-related microbes.
Advantages of Epigenomics Sequencing
- Provides comprehensive analysis of epigenetic modifications including DNA methylation, histone modifications, and chromatin accessibility, offering insights into gene regulation mechanisms.
- Enables single-base resolution mapping of epigenetic marks across the genome, allowing for precise identification of regulatory elements and their modifications.
- Reveals epigenetic alterations associated with diseases, development, and environmental responses, providing insights into cellular memory and inheritance patterns.
- Identifies potential therapeutic targets and biomarkers for epigenetic-based treatments, supporting the development of personalized medicine approaches.
Bioinformatics Pipeline
Service Specifications
Sample Requirement
Genomic DNA, Cultivated cells, Blood, tissues, and other samples.
Please refer to sample submission guidelines or Contact Us!
Sequencing Platform
Illumina NovaSeq 6000/ NovaSeq X
Deliverables
- The original sequencing data
- Experimental results
- Bioinformatics and Data Analysis Report
- Details in Epigenomics Sequencing (customizable)